IFNAR1 and colitis: However, the underlying mechanisms for why decreased expression of IFNAR1 on DCs may promote exacerbation of colitis, whether it be through an impaired ability to induce Tregs or an inability to control proinflammatory cytokine expression, such as IL-17 and IL-13, and whether the level of receptor downregulation we observed has significant immunological effects needs to be investigated further.