MGMT and glioblastoma: One more recently published study on transcriptionalactivity in glioblastomas questions mechanisms of “direct”transcriptional repression by MGMT promoter methylation for aconsiderable number of tumors: Even though overall a strong correlation betweenMGMT promoter methylation and the degree of MGMT mRNAexpression was found [10], discordant findings were seen in at least 15% ofthe investigated tumors, i.e. unmethylated (methylated) tumors expressed low (high)levels of MGMT mRNA.