In tumor tissue as compared to normal brain, DNMT1 andDNMT3b were significantly upregulated (DNMT1: 2.5-fold, DNMT3b: 3.2-fold,p<0.001, Figure 2B); thedegree of upregulation did not correlate with MGMT promotermethylation status and MGMT mRNA expression. This evidence concerns the gene DNMT1 and neoplasm.