MGMT and glioblastoma: Daily clinical practise sometimes indicates discordance between expectations derivedfrom MGMT promoter methylation and outcome, and one more recentlypublished study on transcriptional activity in glioblastomas has questionedmechanisms of “direct” transcriptional repression byMGMT promoter methylation for a considerable number of tumors:Unmethylated (methylated) tumors were found to express low (high) levels of MGMTmRNA in 15% of the study population [10].