Expression of MGMT and DNMTs mRNA were analysed by real-time qPCR.Prognostic factors were obtained from proportional hazards models.Correlation between MGMT mRNA expression and MGMTmethylation status was validated using data from the Cancer Genome Atlas(TCGA) database (N = 229 glioblastomas). The gene discussed is MGMT; the disease is glioblastoma.