ADIPOQ and obesity due to melanocortin 4 receptor deficiency: It is also becoming clear that, as early as in childhood, obesity poses an inflammatory environment both in the adipose tissue [4], [5], [6] and in the circulation, as reflected by increased concentration of inflammatory adipokines (ie, cytokines and chemokines) and reduced levels of adiponectin, an insulin-sensitizing, anti-inflammatory adipose-derived mediator [7], [8], [9].