To explore if abnormalities in TRPC expression can also be demonstrated in non-lesional and lesional skin obtained from psoriasis patients using immunohistochemistry, we analyzed exemplary the expression of the TRPC1-, TRPC4- and TRPC6-channels which are known to be important players in CaR induced Ca2+ influx (Cai et al. 2006; Fatherazi et al., 2007; Müller et al., 2008). This evidence concerns the gene TRPC6 and psoriasis.