ALCAM and neoplasm: With regard to cellular localization, in MTC the surrounding non-tumor tissue (Fig. 7A) and the corresponding tumor tissue (Fig. 7B) showed membranous positive immunostaining, as in the surrounding non-tumor tissue of PTC (Fig. 7C); while in PTC tumor tissue ALCAM staining was localized at the membrane and in the cytoplasm (Fig. 7D).