MAP3K1 and prostate neoplasm: The importance of the MEKK1-dependent pathway of apoptosis has recently been highlighted by Kan et al., who identified MEKK1 as one of the top 50 genes containing somatic missense and nonsense mutations in a panel of breast, lung, ovarian and prostate tumors, indicating that impairment of the MEKK1-dependent apoptotic pathway may enhance tumorigenesis [5].