An example in neurodegenerative disease is the glucocerebrosidase gene (GBA) in Parkinson's disease, individuals homozygous for mutations in this gene present with the Mendelian disorder Gaucher disease, while individuals heterozygous for the same mutations have an increased risk for Parkinson disease [3], [4] The cumulative frequency of GBA mutations in Parkinson disease cases can be as high as 9.0% compared to less than 0.5% in controls. This evidence concerns the gene GBA1 and neurodegenerative disease.