In contrast, CC-3052 treatment resulted in decreased gene expression: tnf-α, −1.63/−1.50; ifn-γ, −1.64/−1.54; il-1β, −1.67/−1.58; and nos2, −1.68/−1.84 at 21 and 28 days post-infection respectively (Figure 3C). The gene discussed is NOS2; the disease is infection.