As we have detected an exacerbation of CNS demyelination in macrophage-depleted mice following ocular infection of mice with wt HSV-1 (unpublished results), we reasoned that the HSV-IL-2 induced demyelination could be due to suppression of the macrophages and an associated alteration in the expression of IL-12p35 and IL-12p40 transcripts. Here, IL2 is linked to eye infection.