The frequencies were 0.76 and 0.24 for the C and T alleles, respectively, of rs11615 (Asn118Asn) of ERCC1, 0.75 and 0.25 for the C and A alleles at 19442C>A of ERCC1 (rs3212986), and 0.63 and 0.37 for the G and A alleles of rs25487 (Arg399Gln) of XRCC1. We found no significant association between any polymorphisms and age, sex, ECOG performance status, disease status, histology, tumour location, or number of organs with metastases (data not shown). This evidence concerns the gene XRCC1 and neoplasm.