BHLHE41 and neoplasm: Notably, the functional classes of genes affected by Kras silencing included tumour suppressors (HMMR, CAV1 and BHLHE41), cell adhesion molecules (CDH1, LGALS4 and PVRL3), genes regulating cellular motility and invasion (ETV4, NT5E and ALDH1A1), cell growth (GCNT3), cell cycle (HPGD, CDKN1A and CAV1), metastasis (CD82) and signal transduction (TM4SF4 and NR2F1).