KRAS and neoplasm: To elucidate the global cellular pathways that are altered in PC cells upon downregulation of the mutant Kras allele, we conducted microarray analysis and observed that most of the genes differentially expressed in the Kras-Scr compared with the shKras cells were associated with cell proliferation, motility and metastatic behaviour of tumour cells (Figure 6A, Supplementary Tables 2 and 3).