ESR1 and breast carcinoma: In PMW undergoing primary treatment for locally advanced ER+/PgR+ breast cancer, letrozole suppressed pretreatment tumour levels of estradiol (E2), estrone (E1), and estrone sulfate (E1S) by 97.6, 90.7, and 90.1%, respectively (Figure 2A) (Geisler et al, 2008).