Two of the contact areas involve iSH2 residues that are mutated in p85α subunit in glioblastomas and were shown to activate p110α, p110β, and p110δ in vitro and in vivo (Parsons et al., 2008; Jaiswal et al., 2009; Wu et al., 2009). The gene discussed is PIK3CD; the disease is glioblastoma.