Several cSH2 truncated versions of p85α have been isolated from cancer cell lines, including p65 (lacking the cSH2 and part of the iSH2) and p76 (lacking the C-terminal 85 residues of the cSH2) (Jimenez et al., 1998; Jücker et al., 2002). This evidence concerns the gene CSH2 and cancer.