Abnormal liver enzymes (aspartate aminotransferase, AST and alanine aminotransferase, ALT) are frequently seen in HIV-1 infected patients and may be due to a variety of factors, such as coinfection with hepatotropic viruses, i.e. hepatitis B (HBV) and C (HCV) viruses, Cytomegalovirus (CMV) and Epstein-Barr virus (EBV), opportunistic infections, cancers, autoimmune hepatitis (AIH), alcohol abuse, and exposure to hepatotoxic drugs, including highly active antiretroviral therapy (HAART). This evidence concerns the gene GPT and cancer.