Abnormal liver enzymes (aspartate aminotransferase, AST and alanine aminotransferase, ALT) are frequently seen in HIV-1 infected patients and may be due to a variety of factors, such as coinfection with hepatotropic viruses, i.e. hepatitis B (HBV) and C (HCV) viruses, Cytomegalovirus (CMV) and Epstein-Barr virus (EBV), opportunistic infections, cancers, autoimmune hepatitis (AIH), alcohol abuse, and exposure to hepatotoxic drugs, including highly active antiretroviral therapy (HAART). This evidence concerns the gene GPT and alcohol abuse.