RORA and neuroblastoma: Inasmuch as estrogens are known to have neuroprotective effects on the brain and RORA has been reported to be neuroprotective against oxidative stress [15] and inflammation [16], we first treated the human neuroblastoma cell line SH-SY5Y with different concentrations of 17β-estradiol, and measured RORA expression by qRT-PCR analyses.