CD4 and relapsing-remitting multiple sclerosis: Indeed, a recentpublication by Weber et al demonstrates that B cells from MOG1–125induced EAE mice activate encephalitogenic T cells in vitro more effectively than Bcells from MOG35–55 induced EAE mice [21], and antigen experienced B cellsfrom RRMS patients also induce inflammatory responses by CD4 T cells in aneuro-antigen specific manner [22].