Therefore, although the ablation of the adrenals reversed the alopecia in CRF-OE mice [11], the fact that astressin-B, at the regimen used, exerted such dramatic effect against the alopecia without affecting plasma corticosterone levels rules out the possibility that peripheral injection of astressin-B exerts a persistent inhibition of the ACTH-corticosterone cascade for such a long period. The gene discussed is CRH; the disease is alopecia.