Successful examples of this approach include identifyingsubtypes of diffuse large B-cell lymphomas with different prognoses and increasedexpression of the zeta-chain (TCR) associated 70 kDa protein kinase(ZAP70) in chronic lymphocytic leukemia (CLL) which is apredictor of the clinical course [1], [2], [3]. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.