In addition, it has recently been shown to suppress HBV replicationin culture [28].Genome wide expression array analysis of both chimpanzee and human liver tissue haveprovided evidence for increased expression of TRIM22 in hepatitis C infected liver,however this is the first report to confirm its increased expression in HCV infectedhuman liver (both cirrhotic and non-fibrotic) using real time PCR [11], [12], [41]. Here, TRIM22 is linked to hepatitis C virus infection.