IFNGR1 and infection: Results showed that IFN-γR−/− mice had significantly increased pulmonary fungal burden compared to WT mice when infected with C. neoformans strain H99γ, but no change in fungal burden was detected between IFN-γR−/− mice and WT mice during infection with the wild-type strain, C. neoformans strain H99 (Figure 3A).