PMP22 and Charcot-Marie-Tooth disease type 1A: However, some CNVs can be inherited in a Mendelian way: Charcot-Marie-Tooth disease type 1A is a dominant neuropathy associated to a duplication of the gene for peripheral myelin protein 22 (PMP22) [7], whereas a deletion of the b-globin gene cluster is responsible for the recessive anemia-thalassemia [8].