APOB and familial hypercholesterolemia: Besides its original usefulness for estimating LDL-C atherogenicity in hypertriglyceridemic patients with TG values outside of Friedewald's formula's range, non-HDL-C is an easy and cost-effective means to estimate apoB levels, while waiting for a consensus whether to use apoB (i) as an alternative to LDL-C for biological assessment of hypercholesterolemia, (ii) as a residual risk assessment tool in dyslipidemia, or (iii) as secondary therapeutic target beyond routine lipids measurement [26-28].