As the majority of T1DM are normolipaemic, combining T1DM and T2DM patients with significant differences in both non-HDL-C and apoB, as well as patients with and without lipid-lowering drug(s), generated an optimal spread of atherogenic lipids and particles number, as required by the DR methodology for assessing the performance of a continuous physiological variable. This evidence concerns the gene APOB and type 2 diabetes mellitus.