Indeed, we and others have previously suggested that induction and maintenance of T-cell acute lymphoblastic leukemia (T-ALL), a devastating pediatric blood cancer, depends on the cross talk of three transcription factors, NOTCH1, MYC, and RELA (NF-κB) [15,19,32]. This evidence concerns the gene NFKB1 and hematopoietic and lymphoid system neoplasm.