In our study, two of the CHEK2 variants, c.470T > C and c.1100delC, were identified in 10 out of 82 analyzed individuals (12.2%) suggesting that the contribution of the two CHEK2 variants to BrCa risk is remarkable in the high-risk Finnish BRCA1/2-founder mutation-negative individuals. Here, BRCA1 is linked to invasive breast carcinoma.