RAD50 and invasive breast carcinoma: As expected, CHEK2 (checkpoint kinase 2), PALB2 (partner and localizer of BRCA2), BRIP1 (BRCA1-interacting protein 1), and RAD50 (human homolog of Saccharomyces cerevisiae RAD50) have been shown to have rare, moderate-risk BrCa-associated variants, which have also been studied in the Finnish population [11-14].