Previously reported PALB2 missense variants, c.1010T > C, c.1676A > G, c.2794G > A, and c.2993G > A were identified here with frequencies from 1.2% to 12.2% in analyzed individuals (Tables 2 and 3) but the variants have not been associated with BrCa risk (an example of the family pedigree of the index individual carrying the c.1676A > G variant in addition to the BRIP1 c.584T > C variant is presented in Figure 7, Family 131). Here, PALB2 is linked to invasive breast carcinoma.