While expression of CD23, CD58, and IL6 have been examined individually either after infection with EBV [6,7,20,21] or after transfection of EBV latency gene LMP1 [10], to our knowledge, this is the first report of identification of sub-populations of B cells based on co-expression of these molecules, marking EBV-infected cells early for different outcomes. Here, CD58 is linked to infection.