The 7 girls with normal FSH and LH concentrations included 3 who were given TBI for acute lymphoblastic leukemia (n = 2) or acute myeloid leukemia (n = 1), one who was given TLI for severe aplastic anemia and 3 who were given chemotherapy alone for congenital immunodeficiency (= 2) or nephroblastoma. This evidence concerns the gene PLOD1 and acute lymphoblastic leukemia.