TAAs are composed of five major groups: cancer/testis (CT) antigens (e.g., MAGE, BAGE, GAGE, NY-ESO-1, [33–35]), mutated antigens (e.g., MUM-1, p53, and beta-catenin [36, 37]), overexpressed antigens (e.g., RCAS1, Survivin, and Her2/neu [38–40]), oncofetal antigens (e.g., Immature laminin receptor and CEA [41, 42]), and differentiation or lineage antigens (e.g., tyrosinase, Melan-A/MART-1, gp100, TRP-1, and TRP-2 [43, 44]). This evidence concerns the gene PMEL and cancer.