We therefore performed a comparative CXCL12/CXCR4 expression analysis and investigated how external addition of CXCL12 would promote CXCR4-mediated migration of CRC cell lines with different metastatic capabilities and how inhibition of CXCR4 by either CXCR4 siRNAs or neutralizing anti-CXCR4 antibodies would influence their migration potential. This evidence concerns the gene CXCR4 and colorectal carcinoma.