Brahmamdam and colleagues showed that the administration of anti-PD-1 antibody 24 hours after cecal ligation and puncture (CLP)-induced sepsis prevented sepsis-induced depletion of lymphocytes and DCs, increased the expression of Bcl-xL, inhibited apoptosis, and improved survival, indicating that PD-1 blockade is a potential promising therapeutic target for sepsis [26]. This evidence concerns the gene BCL2L1 and Sepsis.