The effects of FGFR4 Arg388 allele may also predispose cancer patients to disease progression, based on the reported significant association between FGFR4 genotype and tumor aggressiveness (lymph node involvement, advanced stage) or patients' survival[6,7], and the results about its biological role on cancer cell motility and invasiveness[11]. The gene discussed is FGFR4; the disease is cancer.