As Ecrg4 gene expression is thought to be epigenetically regulated in cancer by hyper-methylation [13-15,17,18], it is particularly interesting to speculate that, in addition to mechanisms like transcription factors that control the response to injury, epigenetic dosing of the Ecrg4 gene expression by methylation might serve to regulate augurin production under physiological circumstances. The gene discussed is ECRG4; the disease is cancer.