The CPE also plays a role in clearance of Aβ from the CSF and it appears that LRP2 is involved in this process, since it has been shown that AD patients have reduced levels of LRP2 at the CP, which may decrease efflux of Aβ from the CSF and could be, therefore, one of the causes of increased brain levels of Aβ [179]. Here, LRP2 is linked to Alzheimer disease.