Consistently, disruption of fetuin-A expression led to significant elevation of serum HMGB1 levels at 48 h post endotoxemia (8226 ng/ml for Fet +/+ mice, versus 181±45 ng/ml for Fet −/− mice; N = 10, P<0.05) or sepsis (125±46 ng/ml for Fet +/+ mice, versus 271±34 ng/ml for Fet −/− mice; N = 12, P<0.05). Here, AHSG is linked to Sepsis.