Variants in bridging integrator 1 (BIN1), clusterin (CLU; also referred to as APOJ), complement component receptor 1 (CR1) and phosphatidylinositol binding clathrin assembly protein (PICALM) have already been reported to show replicable association with risk for AD [5], [6], [7], [8]. Here, BIN1 is linked to Alzheimer disease.