Moreover, activation of HSP-90 appears to be coupled to the activation of IL6/STAT3 [50], and is over expressed in patients with schizophrenia [51], while 14-3-3 proteins were have been reported to be elevated in nucleus accumbens of isolation reared rats [52], and in the posterior hippocampus of post-mortem tissue from patients with schizophrenia [17]. Here, STAT3 is linked to schizophrenia.