However, in agreement with previously published results [32], our real-time PCR data showed that EBV infection led to a significant increase of cyclin D2 mRNA level in LCLs (LCL1 and LCL2) when compared to EBV negative BL cells (BJAB and Ramos) whereas, there was little or no detectable change for cyclin D1 mRNA (Fig. 1F). The gene discussed is CCND1; the disease is Epstein-Barr virus infection.