In addition, patients with tumors over-expressing Cyclin D1 have been shown to have a particularly poor prognosis [25], [29]; however, over-expression of Cyclin D1 has been demonstrated for a vast series of human malignancies including breast cancers, esophageal cancers and pancreatic cancers [25], [30]. Here, CCND1 is linked to familial pancreatic carcinoma.