The modulation of caspase gene expression by viral infections has been reported in humans [59] but also in invertebrates such as lepidopteran, coleopteran species [60] and in the marine shrimp M. japonica. In the shrimp, the infection with white spot syndrome virus induced a significant up-regulation of caspase-3 and -8 [43]. The gene discussed is CASP3; the disease is viral infectious disease.