Recently, we characterized mutations in the F-box only protein 7 (FBXO7) gene, encoding the F-box protein 7 (FBXO7), as the cause of PARK15, an autosomal recessive neurodegenerative disease presenting with juvenile, severe levodopa-responsive parkinsonism and additional pyramidal signs [10]. This evidence concerns the gene FBXO7 and neurodegenerative disease.