Nine genes were common between the ‘C35 genes’ and ‘claudin-low genes’ signatures (Fig. 1): CDH1, CLDN7, CRB3, KRT8, TACSTD1, IRF6, SPINT2, MAL2 and MARVELD3. Five of these, CDH1 (E-cadherin), CLDN7 (Claudin-7), TACSTD1 (EpCAM), IRF6 and KRT8 (Keratin-8) have been previously implicated by their low expression in claudin-low cancers and/or in EMT in vitro[25], [26], [27]. The gene discussed is IRF6; the disease is cancer.