Recently a new family of paraneoplastic and idiopathic CNS disorders with neuropsychiatric symptoms, namely limbic encephalitis with psychiatric features, SPS, hyperexplexia, epilepsy and various other optional features has been identified to be linked to autoantibodies directed at CNS autoantigens including NMDA-receptors, AMPA-receptors, Caspr2 and LGI-1; some of these were formerly classified as voltage-gated potassium channelopathies [30], [31], [32], [33]. This evidence concerns the gene LGI1 and central nervous system disorder.