As shown in Figure 3a and 3b, Ki-67 was co-expressed with only a small subset of LgR5+ cells in areas which were associated with early BE (Cdx-2 positivity was observed in serial sections) (Figure 3a, representative example of n = 41 BE and associated adenocarcinomas) and OE-33 cells (Figure 3b). Here, CDX2 is linked to Barrett esophagus.