LgR5 expression was significantly upregulated in BE (n = 41, Median 33%, IQR 14.75% - 45.0%; 95% CI 24.761 - 39.954%; p < 0.05; Figure 2a) but was decreased in adjacent EAC (n = 41, Median 15%, IQR 13.0% - 18.0%; 95% CI 13.761 - 17.0%; p < 0.05; Figure 2a) and EAC without BE (n = 19, Median 13%, IQR 4.75% - 23.0%; 95% CI 6.346 - 22.436%; p < 0.05; Figure 2a; p < 0.05 for LgR5 expression of BE with adjacent EAC and EAC with and without BE). The gene discussed is LGR5; the disease is Barrett esophagus.