Multivariate analysis using the Cox Proportional Hazards Model demonstrate lymph node metastasis and grading but not LgR5 expression as independent prognostic factors in all (n = 60) EACs (LN positive: Exp (b) 9.1861; 95% CI of Exp (b) 2.0665 - 40.8346; p = 0.003746. This evidence concerns the gene LGR5 and metastatic malignant neoplasm in the lymph nodes.