LDLR and familial hypercholesterolemia: The LDL-R gene Ava II polymorphism was also found to be associate with the variability of plasma or serum lipid levels in subjects presenting a lipid profile with high risk for CHD [38], in normal individuals from five Brazilian Indian tribes [39], in males with hypercholesterolemia [43], in cases with acute myocardial infarction [45], in patients with CHD [46], and in population with phlegm-dampness constitution [47].