KIDINS220 and cutaneous melanoma: We have demonstrated that ARMS (ankyrin repeat-rich membrane spanning), a neuron-enriched transmembrane molecule interacting with Trk, p75NTR, Eph, and protein kinase D (Iglesias et al, 2000; Kong et al, 2001; Chang et al, 2004), is overexpressed in cutaneous melanoma, while normal melanocytes and benign nevi reveal negative or weak expression of ARMS (Liao et al, 2007).