Similarly, ARMS silencing in mouse B16-F10 melanoma cells significantly demised the migration potential of tumour cells in wound scratch assay (17.8±3.1 μm h–1 for ARMS–RNAi vs 26.5±2.9 μm h–1 for control) and led to a significant decrease in their invasive capability (169±17.6 cells per 100 × field in control cells vs 35±4.4 cells in ARMS–RNAi cells; Figure 3F; Student's t-test, P<0.01). The gene discussed is KIDINS220; the disease is melanoma.