For example, although phosphoenolpyruvate does not overlap with any of the EHMN annotated direct reaction genes in Figure 2B, it has high correlation with GPI and ALDOA, two of the genes in the glycolysis module that are known to be highly regulated by hypoxia-inducible factor 1alpha and such regulation is related to the aggressive phenotype of hepatocellular carcinoma. This evidence concerns the gene ALDOA and hepatocellular carcinoma.