Cdc37 (Cell division cycle protein 37), one of the essential co-chaperone of Hsp90, plays a specialized and indispensable role in the maturation of a number of kinase clients, whose functions are commonly dysregulated in cancer, such as receptor tyrosine kinases like epidermal growth factor receptor (EGFR), non-receptor tyrosine kinases Src and lymphocyte specific protein tyrosine kinase (Lck), and intracellular serine/threonine kinases such as Raf-1and Cdk4 [28]. The gene discussed is HSP90AB1; the disease is cancer.