In conclusion, entecavir is superior to adefovir in decreasing serum HBV DNA and normalizing ALT, but similar with adefovir in clearing HBeAg and encouraging HBeAg seroconversion for the HBeAg-positive nucleos(t)ide-naive Asian patients with chronic hepatitis B. Adefovir can be still used for first-line therapy in these patients. Here, GPT is linked to chronic hepatitis B virus infection.