IGHE and allergic disease: Considering the above, Shimata et al., 2007, investigated the effects of using oral antibiotics in weaned mice, and the influence of oral consumption either associated or not to LFK (FK-23 Enterococcus faecallis lysate) on the local buildup of allergy-induced eosinophils, the levels of total IgE, antigen-specific IgE and IgG2a in the serum and on the intestinal micro flora.