IGHE and allergic disease: Showing a protective effect of probiotics in allergy, Morita et al., 2006, utilized fermented milk with TMC0356 Lactobacillus gasseri in 15 individuals with high serum IgE and allergic rhinitis, in the dose of 200ml/day during 4 weeks and observed a significant decline (p<0.05) in the total IgE serum levels, as well as specific IgE for mite and Japanese cedar pollen, after 28 days of exposure compared to the baseline value; besides these findings, there was an increase in the number of TH1 cells.18