A critical E3 ubiqutin ligase mediating the ubiquitiation-dependent receptor endocytosis is the proto-oncogene Casitas B-lineage lymphoma (Cbl), which was first identified as the cellular homolog of v-cbl, which induces pre-B-cell lymphomas and myeloid tumors [8], [9]. The gene discussed is CBL; the disease is myeloid neoplasm.