Sorafenib is a potent multikinase inhibitor that targets the Raf/MEK/ERK pathway, as well as VEGFR1/2/3, PDGFR-β, KIT, Flt-3, and RET,[11] and has been approved in several countries worldwide for the treatment of renal cell carcinoma and HCC.[10], [13] In the SHARP study, sorafenib was both effective and safe in patients with advanced HCC,[10], [11], [12] but Child–Pugh liver function class B or C was an exclusion criterion.[10] Importantly, this classification does not evaluate the severity of portal hypertension, but reflects the extent of biological and clinical complications of cirrhosis. Here, MAP2K7 is linked to hereditary clear cell renal cell carcinoma.