Sorafenib (BAY-43-9006 Nexavar®, Bayer Pharmaceuticals Corp., Wayne NJ and Onyx Pharmaceuticals Inc., Emeryville CA), an oral multikinase inhibitor of the VEGF and the PDGF receptors and Raf, decreases tumor growth and inhibits angiogenesis in advanced HCC [10], [11], [12]. Here, VEGFA is linked to neoplasm.