Barley β-glucans also enhance the anti-tumor effect of monoclonal antibodies in mice when administered orally [16,31] by being taken up by gastrointestinal macrophages, transported to the spleen, lymph nodes and bone marrow where smaller fragments of glucan are bound to CR3 on granulocytes which in turn kill iC3b-opsonized tumor cells [15]. Here, CRIPTO3 is linked to neoplasm.