CD28 and neoplasm: Using flow cytometry, Pages et al. [68] found that TILs from tumours with no sign of metastasis showed higher expression of markers of cell adhesion (CD62L, CCR7, CD103, CD49d and CXCR3), activation (HLA-DR, CD98, CD80, CD86 and CD134) and differentiation (CD45RO, CD45RA, CD27, CD28, CCR7 and CD127).